Utility of thieno[2,3-b] pyridine derivatives in the synthesis of some condensed heterocyclic compounds with expected biological activity

On the pharmaceutical account of the reported anticancer activity of thieno[2,3-b] pyridine and condensed thieno[2,3-b] pyridine, new compounds containing thieno[2,3-b] pyridine condensed with each of pyridine, cyclopentyl, tetrahydroquinoline, pyrimidine, 1,6-naphthiridin, benzofuro[2,3-b] pyridine, imidazo[1,2-c] pyrimidine, [1,2,3] triazolo[1,5-a] pyrimidine were synthesized through different chemical reactions. The obtained compounds were evaluated for their in vitro antitumor activity against Liver HepG-2 and Breast MCF-7 cell lines compared to the reference drug (doxorubicin). Compounds 5, 7, 12, 23, 24, 37 and 39 were found to be the most active against both cell lines exhibiting IC50 values ranging from 10.33-43.90 μM/L and 9.70-48.80 μM/L against HepG-2 and MCF-7 cell lines; respectively. From which compound 5 was the most active compound exerting comparable activity to the reference drug against both cell lines, showing IC50 values 10.33 and 9.70 μM/L comparable to doxorubicin that exerted IC50 values 8.55 and 8.90 μM/L against HepG-2 and MCF-7 cell lines; respectively.